ANALISA PENGUJIAN KADAR ASAM SULFAT PEKAT TEKNIS DENGAN METODE QUALIFICATION AND VERIFICATION METHOD
DOI:
https://doi.org/10.70248/jmie.v2i4.2410Abstract
Asam sulfat (H₂SO₄) adalah bahan kimia anorganik penting dalam industri, yang memerlukan analisis kualitas yang tepat dan valid. Penelitian ini bertujuan untuk menganalisis kadar asam sulfat pekat teknis melalui metode kualifikasi dan verifikasi. Metode ini memastikan bahwa alat dan sistem pengujian berfungsi sesuai spesifikasi serta menghasilkan data yang akurat. Kualifikasi alat meliputi tahap Design Qualification, Installation Qualification, Operational Qualification, dan Performance Qualification. Penelitian dilakukan dengan analisis titrasi menggunakan larutan NaOH standar, di mana data dianalisis secara statistik untuk mengukur presisi dan akurasi. Hasil menunjukkan bahwa pengujian dengan kadar NaOH 0,75 memberikan efektivitas dan pengurangan biaya yang signifikan. Penelitian ini juga mengembangkan prosedur analisis yang sesuai dengan standar mutu untuk digunakan dalam pengujian rutin.
References
A Basic Guide to IQ, OQ, PQ in FDA-Regulated Industries. (2024). The FDA Group Blog.
A comparative study of Mohr, Fajans, and Volhard techniques. (2024). Analytical Chemistry Journal.
A reagent-free acid–base titration method via an electrodialytic titrant. (2021). Analytica Chimica Acta.
Kulwant, G. S., Rawat, S., Jaybhaye, S., Muley, Y., & Phoke, S. (2024). A Review on Qualification of Laboratory Equipment. EPRA International Journal of Multidisciplinary Research, 10(11). doi: 10.36713/epra2013
A Review on Validation. (2024). IRJMETS, 11.
Development and validation of an acid/alkaline digestion method for heavy metals monitoring. (2024). Environmental Research.
Development of analytical methods and method validation for the monitoring of pharmaceuticals. (2024). Journal of Pharmaceutical and Biomedical Analysis.
Equipment Validation and Calibration in Pharma. (2024). JETIR, 11(6).
Max, J.-J., Ménichelli, C., & Chapados, C. (2000). Infrared Titration of Aqueous Sulfuric Acid. J. Phys. Chem. A.
Harmonisation, I. C. for. (2024). Q2(R2) Validation of Analytical Procedures. FDA Guidance.
Oca, L., Campillo, J. M., & Bou Ali, M. M. (2025). Review and Analysis of Thermophysical Properties of a Sulfuric Acid–Water Electrolyte.
Standard Test Method for Total Acidity of Sulfuric Acid (E223–23E01). (2023). ASTM International. doi: 10.1520/E0223-23E01
Statistical validation of sulfate quantification methods for acid mine drainage. (2025). Environmental Laboratory Diagnostics.
Eronen, E. A., Vladyka, A., Sahle, C. J., & Niskanen, J. (2024). Structural Descriptors and Information Extraction from X-ray Emission Spectra: Aqueous Sulfuric Acid.
Thermodynamic modeling and experimental measurement of titration curves for sulfuric acid. (2023). Journal of Molecular Liquids.
Thermodynamics of Electrolytes. 7. Sulfuric Acid. (2023). Journal of Chemical & Engineering Data, 68, 2554–2562.
Toledo, M. (2021). Titration Guide on Errors. Application Note.
Titration of Unknown Sulfuric Acid. (2023). CliffsNotes Study Notes.
Validation characteristics and statistics in analytical method development. (2022). ResearchGate.
Validation of a fast automated photometric method for the analysis of sulfur dioxide in wines. (2024). European Food Research and Technology, 250, 1611–1618.
